Depression Archives - Page 2 of 2 - Food for the Brain

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Iron & Depression (2007)

This study investigated iron & depression. Two hundred women who were not anaemic had their mood and blood iron levels measured. The iron levels in the women who were rated as depressed (67) were significantly lower than in the healthy controls (125).

M Vahdat Shariatpanaahi et al., ‘The relationship between depression and serum ferritin level’, European Journal of Clinical Nutrition, 61; 532-535, 2007

Click here for the abstract.

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Vitamins, Minerals & Mood (2007)

This study investigated vitamins, minerals & mood. 225 hospitalised acutely ill elderly people were either given a normal hospital diet plus multivitamin and mineral supplements (providing 100 per cent of the Reference Nutrient Intakes for a healthy older person for vitamins and minerals), or a normal hospital diet plus a placebo for six weeks. Measures of mood and mental agility were taken at the start, at six weeks and six months later. There were significant differences in symptoms of depression scores in the supplement group compared with the placebo group at 6 months. This effect was seen in all patient groups including those with no symptoms of depression, mild depression and those with severe depression.

Click here for the abstract

Gariballa S and Forster S, ‘Effects of dietary supplements on depressive symptoms in older patients: A randomised double-blind placebo-controlled trial.’  Clin Nutr. 2007 Jul 25

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Folate & Depression (2004)

This review explored folate & depression. A review of all randomized controlled trials that compared treatment with folic acid or 5′-methyltetrahydrofolic acid to an alternative treatment, for patients with depression. Three randomized trials (247 participants) were included. Two studies assessed the use of folate in addition to other treatment, and found that adding folate reduced Hamilton Depression Rating Scale (HDRS) scores on average by a further 2.65 points [95% confidence interval (CI) 0.38-4.93]. The remaining study found no significant difference when folate alone was compared with trazodone. The limited available evidence suggests folate may have a potential role as a supplement to for depression. It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency.

M J Taylor, ‘Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.’, J Psychopharmacol., 18(2):251-6, 2004

Click here for the abstract

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Mediterranean Diet & Depression (2009)

This study investigated the mediterranean diet & depression.  In a study of over 10,000 healthy Spanish participants – those who followed a Mediterranean diet most closely had a greater than 30% reduction in the risk of depression.

The specific mechanisms which help to prevent the occurrence of depression are not well known, however, the authors suggest that the role of the overall dietary pattern may be more important than the effect of single components. It is plausible that the synergistic combination of a sufficient provision of omega-three fatty acids together with other natural unsaturated fatty acids, antioxidants from olive oil and nuts, flavonoids and other phytochemicals from fruit and vegetables and increase levels of folate and other B vitamins in the overall Mediterranean diet may exert a fair degree of protection against depression.

Click here for the abstract

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Essential fatty acids & mental health (2005)

The study investigated essential fatty acids & mental health. A review finds that there is an association between depression and low dietary intake of omega-3 fatty acids and that low levels of the fatty acids in red blood cell membranes are found in both depressive and schizophrenic patients. Five of six double-blind, placebo-controlled trials in schizophrenia, and four of six such trials in depression, have reported therapeutic benefit from omega-3 fatty acids in particularly when EPA is added on to existing psychotropic medication. Individual clinical trials have suggested benefits of EPA treatment in borderline personality disorder and of combined omega-3 and omega-6 fatty acid treatment for attention-deficit hyperactivity disorder. The evidence to date supports the use of omega-3 fatty acids in the management of treatment unresponsive depression and schizophrenia alongside medication. As these conditions are associated with increased risk of coronary heart disease and diabetes mellitus, omega-3 fatty acids should also benefit the physical state of these patients.

Peet & Stokes, ‘Omega-3 fatty acids in the treatment of psychiatric disorders ‘, Drugs, 65(8):1051-9, 2005

Click here for the abstract

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Nutritional & lifestyle changes to support SAD

SAD, which stands for Seasonal Affective Disorder, isn’t just a case of the winter blues. It is a form of major depression and can be seriously debilitating, causing symptoms such as chronic low mood, excessive sleeping, carbohydrate cravings, irritability, poor concentration, low libido and lethargy. SAD occurs most typically throughout the winter months and currently affects around 6% of the UK population, and between 2-8% of people in other countries of higher latitude such as Sweden, Canada and Denmark. 

Curiously, around 80% of sufferers are women, mostly those in their early adulthood. Scientists such as Dr Robert Levitan, professor at the University of Toronto, have speculated that this may be due to evolutionary purposes, which encourages women of reproductive age to slow down during the winter months to help preserve energy, leading to healthier pregnancies. 

Research has yet to come to a definitive conclusion as to what causes SAD, however, there are a number of underlying biochemical triggers that have been identified. 

A leading theory looks at serotonin production and how levels of this neurotransmitter in the body are significantly affected by the amount of available sunshine. Research shows that exposure to sunshine has an impact on the binding-capacity of serotonin to receptor sites in the brain, which essentially allows serotonin to work its magic, leading to feelings of contentment and happiness. 

Other research also indicates how those suffering with SAD tend to have a dysregulated production of melatonin, the hormone produced in the pineal gland in response to darkness, which induces sleep. Instead of being produced in the evening, helping the body settle for the night, studies in those that suffer with SAD show melatonin being secreted during the day, hence feeling the need to sleep all the time and lack of energy. 

There are a few other biochemical underpinnings in the pathogenesis of SAD, however, there are some key nutrition and lifestyle strategies based on these initial findings, which can help support mood throughout the winter months.  

1. Get your body clock in check 

Our body’s hormones and biological processes are majorly governed by a natural, internal circadian rhythm, which regulates our sleep-wake cycle and is programmed by daylight and night. A disrupted circadian rhythm can be caused by shift work, not enough exposure to daylight, stress, insomnia and too much exposure to blue light in the evening, which can lead to an imbalance in neurotransmitters such as serotonin and melatonin. 

This is why it is incredibly important to try and attune the body to these cycles as much as possible, by doing things like avoiding electronic screens at night and doing relaxing activities to encourage melatonin production, as well as exposing the face to daylight first thing in the morning, or if it’s dark, buying a light therapy lamp. Putting these strategies into place, can help the body recalibrate and realign to a healthy sleep-wake cycle. 


2. Check your vitamin D levels

Research shows that having sub-optimal levels of vitamin D3 can interfere with proper serotonin production. Whilst scientists don’t understand exactly how, there is a significant body of research that demonstrates a strong link between vitamin D3 levels and depression.In one particular study, scientists found that vitamin D3 helps to convert the amino acid, tryptophan, into serotonin. 

Check your vitamin D3 levels and make sure that they are above 75 nmol/L, for optimal serotonin production. 


3. Balance your blood sugar levels 

More than any other organ in the body, the brain is dependent on a constant supply of energy, which very much related to our diet. Eating foods that are high in sugar and simple carbohydrates leads to rapid fluctuations in blood sugar levels, which can have a significant impact on the brain and its neurotransmitters. Typical symptoms of imbalanced blood sugar levels are low mood, anxiety, brain fog and fatigue. 

This is why it is important to eat foods that provide the body and brain with a consistent and sustainable source of energy. This means making sure you’re eating complex carbohydrates that contain ample amounts of fibre, such as brown rice, starchy vegetables and tubers like sweet potato, butternut squash and beets, as well as eating protein-rich foods with every meal and snack. Avoiding refined grains like white bread, pastries, cakes, biscuits and white rice, as well as foods with added sugar like in processed foods, sweet yoghurts, fruit juices and cereals, is absolutely key to avoiding blood sugar imbalances. 
4. Get moving! 

According to a recent study published by JAMA Psychiatry, people are 26% less likely to become depressed with regular physical activity. It is well established that exercise can stimulate the release of endorphins such as serotonin, dopamine and norepinephrine – all of which regulate mood and prevent symptoms of depression. 

We also know that exercise stimulates the release of protective molecules such as Brain-Derived Neurotrophic Factor, which helps to trigger the growth of new brain cells. 

The key takeaway is to include some form of movement into your everyday life to help encourage the brain to produce its ‘feel-good chemicals’. Whether it’s fast paced walking or a more intensive exercise like HIIT, it is vital to be moving. 

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