Like many people, I enjoy a glass of wine or two a few times a week (perhaps more at times of celebration and holidays). Alcohol makes me feel happy, relaxed and sociable, and a little bit of red wine is good for you, isn’t it? “Dry January” hadn’t appealed before, but this year the scientist in me was intrigued to find out if short-term abstinence can really make a difference to brain health.

What I found was genuinely surprising! For healthy people with a moderate or heavy alcohol consumption, a month’s abstinence from alcohol can lead to significant improvements in blood sugar control, blood pressure, weight loss and a reduction in cancer related factors; all of which can affect brain health and mental wellbeing. In addition, moderate drinkers who avoid alcohol for a month will reduce the risk of liver cell damage because oxidative cellular stress is reduced. I couldn’t find any studies that prove this has a knock-on effect on brain health (for obvious reasons), but what is good for the liver is most usually beneficial for the brain too.

I also discovered that good dietary sources of folate and riboflavin (vitamin B₂) may be protective of cognitive function following a period of regular alcohol intake. It does this by helping to reduce homocysteine levels, which is an important biomarker for brain health.

This next bit of information will be disappointing for many people (myself included). The perceived connection between a little bit of red wine and good health is being eroded by science. Yes, red grapes and red wine contain a polyphenol called resveratrol that has been found to be beneficial for rat brains, but research doesn’t support the view that drinking wine is as beneficial for human cognition as eating the grapes. 

With all this in mind, how to approach lifestyle change, even if short-term? For me, I prefer to slowly reduce consumption in order to give my liver and brain a chance to wind down naturally. For others, it’s easier to get started knowing that others are doing it too. Whichever route you choose, research does show that as soon as we reduce our alcohol consumption and initiate some longer-term changes like eating well and taking more exercise, the sooner we can feel more energised and develop healthier drinking patterns!

I’ve changed my mind about Dry January. It’s not about depriving ourselves of enjoyment, it’s about getting ourselves and our brain back in harmony so we can make 2022 an awesome year. This January I will be raising a glass of elderflower cordial and saying “Cheers” to that!

With thanks to Tracey Hipkiss, Food for the Brain Volunteer, for this article.

This study explored stress & food preferences. 232 Flemish students completed a food frequency questionnaire and psychological tests to measure stress levels, during exam period, to determine effects of stress on food choices as part of a longitudinal study.

Results

Diet quality of the students was observed to deteriorate during the exam period in response to stress, with preferences for high fat and sugar foods increased. The study indicated that chronic stress alters food preferences to high fat and high sugar foods. However, the data was from food frequency questionnaires and self reported measures of stress levels. These methods are vulnerable to self reporting biases. Further research which monitors diet whilst taking serum samples of cortisol and other stress-related markers are required to explore these findings further.

Abstract available here

Michels, N., Man, T., Vinck, B., & Verbeyst, L. (2020). Dietary changes and its psychosocial moderators during the university examination period. European journal of nutrition, 59(1), 273–286.

Exercise plays an important role in cognition. In this TED talk listen to expert Dr Wendy Suzuki explaining in more detail.

Dr Wendy Suzuki – The Brain Changing Benefits of Exercise (TED).

This study investigate bilingualism & cognition. The study was a meta analysis of studies. Inclusion criteria was studies investigating bilingualism in the elderly with relation to Alzheimer’s disease risk. 6 prospective cohort studies were selected and 8 retrospective studies were selected. Of the 14 studies, only 2 had a monolingual control group. 14 studies selected for analysis. Study indicated that bilingualism may be protective against memory decline in older adults.

Results:

Meta analysis indicates that one exception, the studies support the idea that bilingualism reduces risk of memory decline. . However, only a small sample of studies included, although selected studies generally of a good sample size (>500). Only two of the studies included participants with Alzheimer’s disease diagnosis. Moreover, only two studies had a control group. Further, two of the studies included only Hispanic subjects, which may have impacted results.

A notable limitation of the meta analysis is that it did not include any statistical analysis methods (i.e p value) and this is a significant limitation. Further large scale research is required to explore effects of bilingualism on cognition, and whether bilingualism may be protective against cognitive decline.

Abstract available here

Klimova, B., Valis, M., and Kuca, K. (2017). Bilingualism as a strategy to delay the onset of Alzheimer’s disease. Clin. Interv. Aging 12, 1731–1737.

This study investigated bilingualism & cognition. Study included 28 older adult participants – 14 monolingual participants and 14 bilingual participants (who had been bilingual since before age 11). All participants were subjected to a fMRI and had no diagnosed mental health conditions.

Results indicated:

Bilingual participants performed better on tasks and had better working memory (p<0.01) and better connectivity (p=0.002), compared with the monolingual group (p=0.17)

Results observed for other types of memory were not significant

Study size was small. Further large scale warranted. Study did not specify regarding bilingualism, as to whether participants spoke more than 2 languages, or whether certain type and complexity of language afford greater protection (i.e romance languages, Germanic languages etc.). Further research merited to explore effects of bilingualism on other types of memory.

Abstract available here

Grady, C. L., Luk, G., Craik, F. I., and Bialystok, E. (2015). Brain network activity in monolingual and bilingual older adults. Neuropsychologia 66, 170–181. doi: 10.1016/j.neuropsychologia.2014.10.042

In this study memory change over 6 years was assessed using a large scale sample (16, 638 elderly individuals born <1948) from Health and Retirement Study. Growth curve models were analysed with reference to memory recall of a 10 word list and levels of social integration (i.e with family, volunteering, marital status).

Results indicated:

Socialisation demonstrated as a predictor of slower memory decline (p<.01). 

In individuals with vascular disease, socialisation observed to be protective buffer ( (p< 0.05)

Memory amongst least socialised deteriorated at twice the rate of other participants, with association greatest amongst those with <12 years of education (p<0.07)

The study indicates that socialisation and levels of education may be protective factors for memory decline. The study also suggests that socialisation may reduce risk for memory decline in individuals with vascular diseases. The study did not use a robust means of measuring memory capability, such as MMSE. Results for socialisation as a predictor of slower memory decline not statistically significant. However, socialisation in individuals with vascular disease as a protective factor was observed to be statistically significant. More research required as to the mechanisms of how socialisation reduces risk of memory decline in vascular disease. Findings for education as a protective factor were observed to be statistically significant. More research required into to what level of education is most protective against memory decline.

Abstract can be viewed here

Ertel, K. A., Glymour, M. M., & Berkman, L. F. (2008). Effects of social integration on preserving memory function in a nationally representative US elderly population. American journal of public health, 98(7), 1215–1220.

This study explored fasting & cognitive performance. It identified that biological ageing is a process which is accelerated and exacerbated by excessive calories and a sedentary lifestyle. Further, these factors combined may increase the risk of developing neurodegenerative diseases. This systematic review explored the role of different types of IF (intermittent fasting) on cognitive function, with specific focus on BDNF (brain derived neurotrophic factor) as a marker. Reduction of levels of BDNF has been associated with cognitive decline and increased risk of Alzheimer’s disease. Moreover, reductions in BDNF may result in a reduction in synaptic plasticity, memory and learning.

The study accepted and appraised 82 papers. Key findings were:

IF modulated BDNF supporting synaptic maturation and function

Primary evidence demonstrates pro-cognitive and neuroprotective effects of IF and BDNF

Sex specific differences were observed in response to IF

IF was suggested to be supportive for brain health and sustaining cognitive performance into old age, although it was identified further research is required into this area

The abstract is available here:

Seidler, K., & Barrow, M. (2021). Intermittent fasting and cognitive performance – Targeting BDNF as potential strategy to optimise brain health. Frontiers in neuroendocrinology, 65, 100971. Advance online publication. https://doi.org/10.1016/j.yfrne.2021.100971