Homocysteine & Brain Shrinkage (2011)

This study investigated homocysteine & brain shrinkage. UCLA School of Medicine researchers inlcuding a sample of 732 elderly people subjected to MRI brain scans, found that those with raised homocysteine levels have greater brain shrinkage regardless of age and diagnosis. Among those with cognitive impairment, the greater the homocysteine level the greater was the brain atrophy. The authors state ‘ Vitamin B supplements such as folate may help prevent homocysteine-related atrophy in Alzheimer’s disease by possibly reducing homocysteine levels.’

Click here for the abstract

Rajagopalan, P., Hua, X., Toga, A. W., Jack, C. R., Jr, Weiner, M. W., & Thompson, P. M. (2011). Homocysteine effects on brain volumes mapped in 732 elderly individuals. Neuroreport22(8), 391–395. https://doi.org/10.1097/WNR.0b013e328346bf85