because prevention is better than cure.

because prevention is better than cure.

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Socialisation, Education & Cognition (2008)

In this study memory change over 6 years was assessed using a large scale sample (16, 638 elderly individuals born <1948) from Health and Retirement Study. Growth curve models were analysed with reference to memory recall of a 10 word list and levels of social integration (i.e with family, volunteering, marital status).

Results indicated:

Socialisation demonstrated as a predictor of slower memory decline (p<.01). 

In individuals with vascular disease, socialisation observed to be protective buffer ( (p< 0.05)

Memory amongst least socialised deteriorated at twice the rate of other participants, with association greatest amongst those with <12 years of education (p<0.07)

The study indicates that socialisation and levels of education may be protective factors for memory decline. The study also suggests that socialisation may reduce risk for memory decline in individuals with vascular diseases. The study did not use a robust means of measuring memory capability, such as MMSE. Results for socialisation as a predictor of slower memory decline not statistically significant. However, socialisation in individuals with vascular disease as a protective factor was observed to be statistically significant. More research required as to the mechanisms of how socialisation reduces risk of memory decline in vascular disease. Findings for education as a protective factor were observed to be statistically significant. More research required into to what level of education is most protective against memory decline.

Abstract can be viewed here

Ertel, K. A., Glymour, M. M., & Berkman, L. F. (2008). Effects of social integration on preserving memory function in a nationally representative US elderly population. American journal of public health, 98(7), 1215–1220.

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Omega 3 & Cognitive Decline (2007)

This study investigated omega 3 & cognitive decline. This was a prospective study of 2,000 people aged 50 to 65 years old. Results indicated that risk of global cognitive decline increased with elevated palmitic acid in both fractions and with high arachidonic acid and low linoleic acid in cholesteryl esters. Higher n-3 HUFAs reduced the risk of decline in verbal fluency, particularly in hypertensive and dyslipidemic subjects.

M A Beydoun, ‘Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study’, Am J Clin Nutr., vol 85(4):1103-1111, 2007

Click here for the abstract

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Fish Oil & Cognitive Decline (2007)

This study investigated fish oil & cognitive decline. 210 men aged 70 to 89 years old were followed for 5 years. There was a significant association between intake of fish oil (EPA and DHA) from diet and rate of cognitive decline, with those taking in the most fish oil from oily fish showing the least decline. The measure of decline used the Mini-Mental State Exam (MMSE) which includes questions on orientation to time and place, registration, attention and calculation, recall, language, and visual construction.

B M van Gelder et al, ‘Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study’ American Journal of Clinical Nutrition, vol (85)4; 1142-1147, 2007

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Calcium & Cognitive Decline (2007)

A total of 4,500 elderly people were involved in a 5-11 year study of the effects of blood calcium levels on cognitive decline. Cognitive function was measured using the Mini-Mental State Examination (MMSE) and other measures of attention and memory. Higher levels of blood calcium (but still within the normal levels) was associated with worse cognitive function at the beginning of the study. They were also associated with a faster rate of decline in cognitive function during follow-up.

Schram MT et al, ‘Serum calcium and cognitive function in old age’, J Am Geriatr Soc. 2007 Nov;55(11):1786-92

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Cognitive Performance & Fish Intake (2007)

This study examined the relationship between cognitive performance & fish intake. The study included 2,031 elderly Norwegians. The researchers report those eating at least 10 grams of fish a day performed significantly better in tests for cognitive performance, compared with people who ate less than 10 grams of fish and fish products. The best test scores occurred in those who consumed the most fish and fish products, which equates to 75 grams per day. Positive effects were observed to be more pronounced in unprocessed fish compared with processed fish intake. Interestingly, there was no significant difference between the consumption of lean or fatty fish, suggesting that the effects were due to something other than omega-3 fatty acids. However, further research is required to explore this area further.

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Nurk E et al., ‘Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study’, Am J Clin Nutr. 2007 Nov;86(5):1470-8

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Omega 3 & Cognitive Performance (2007)

This research investigated omega 3 & cognitive performance. Dutch researchers used data from a trial involving 404 men and women (average age 60 at the start). The researchers report that higher blood levels of omega-3 fatty acids was associated with a 60 % lower decline in mental processing speed over three years.

Dullemeijer C et al., ‘n 3 Fatty acid proportions in plasma and cognitive performance in older adults’, Am J Clin Nutr. 2007 Nov;86(5):1479-85

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Homocysteine & Brain Atrophy (2002)

The study investigated homocysteine & brain atrophy. Through MRI examination of the brains of 36 healthy elderly individuals, results indicated that there appears to be an association between brain atrophy (shrinking) and higher levels of homocysteine. However, due to the small sample size further research is required to substantiate these findings further.

P S Sachdev et al., ‘Relationship between plasma homocysteine levels and brain atrophy in healthy elderly individuals’, Neurology, 58(10):1539-41, 2002

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Homocysteine associated with brain atrophy in the healthy elderly. Sachdev, Neurology, 58(10):1539-41, 2002

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Vitamin D & Cognition (2006)

This study examined vitamin D & cognition. Vitamin D status, cognitive performance, mood, and physical performance in older adults was assessed. 58% of the participants were found to have abnormally low vitamin D levels. Vitamin D deficiency was associated with presence of a mood disorder and with worse performance on 2 measures of mood and cognitive performance.

C H Wilkins et al., ‘Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults’, J Geriatr Psychiatry, 14(12):1032-40, 2006

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Homocysteine & Brain Shrinkage (2011)

This study investigated homocysteine & brain shrinkage. UCLA School of Medicine researchers inlcuding a sample of 732 elderly people subjected to MRI brain scans, found that those with raised homocysteine levels have greater brain shrinkage regardless of age and diagnosis. Among those with cognitive impairment, the greater the homocysteine level the greater was the brain atrophy. The authors state ‘ Vitamin B supplements such as folate may help prevent homocysteine-related atrophy in Alzheimer’s disease by possibly reducing homocysteine levels.’

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Rajagopalan, P., Hua, X., Toga, A. W., Jack, C. R., Jr, Weiner, M. W., & Thompson, P. M. (2011). Homocysteine effects on brain volumes mapped in 732 elderly individuals. Neuroreport22(8), 391–395. https://doi.org/10.1097/WNR.0b013e328346bf85

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B12 & Cognition (2011)

This study investigated B12 & cognition.  This study compared markers of vitamin B12 deficiency with various measures of brain shrinkage (MRI scans) and function (neuropsychological test results) over a 5 year period.  Results indicated that Methylmalonate, a specific marker of B12 deficiency, may affect cognition by reducing total brain volume. However, the effect of homocysteine (nonspecific to vitamin B12 deficiency) on cognitive performance may be mediated through increased white matter hyperintensity and cerebral infarcts.

Tangney CC, Aggarwal NT, Li H, Wilson RS, DeCarli C, Evans DA, Morris MC (2011) Vitamin B12, cognition, and brain MRI measures – A cross-sectional examination. Neurology 77:1276-1282

 Click here for abstract

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